Murrayone
Based on 1 Customer Validation
Murrayone is a coumarin compound with antifungal and antiplatelet activities. Murrayone disrupts fungal redox homeostasis, impairs cell membrane integrity, inhibits sporulation, spore germination and hyphal growth, and causes morphological damage to fungal cells. Murrayone reduces the disease severity of blueberry fruits infected with Botrytis cinerea. Murrayone can be used in studies related to fungal infections and vascular diseases.
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- Pureza: 99.44%
- No. CAS: 19668-69-0
- Fòrmula: C15H14O4
- Peso molecular:258.27
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
Murrayone (10-50 μg/mL; until mycelia cover at least two-thirds of the plate area) potently inhibits the mycelial growth of Botrytis cinerea strain Bc05.10 in a concentration-dependent manner, with an EC50 value of 39.18 μg/mL, and induces severe abnormalities in mycelial morphology[1].
Murrayone (40 μg/mL; 15 days) significantly reduces spore production of Botrytis cinerea strain Bc05.10[1].
Murrayone (25-200 μg/mL; 12 h) inhibits spore germination of *Botrytis cinerea* strain Bc05.10 in a concentration-dependent manner, with an almost complete inhibition rate (92.72%) at 200 μg/mL[1].
Murrayone (100-300 μg/mL; 12 h soaking, 5 days incubation) exerts no adverse effect on the germination rate of cucumber seeds of the Jinyan 4 cultivar, and promotes root growth at the concentration of 200 μg/mL[1].
Murrayone (40 μg/mL; 3 days) induces extensive differential gene expression in the mycelia of *Botrytis cinerea* strain Bc05.10, with significant enrichment of pathways related to oxidative stress responses and cell membrane functions[1].
Murrayone (50-200 μg/mL; applied 12 h after 48 h of initial culture) disrupts the mycelial cell membrane integrity of Botrytis cinerea strain Bc05.10 in a concentration-dependent manner[1].
Murrayone (20-100 μg/mL; 5 days) reduces the dry weight of mycelia of Botrytis cinerea strain Bc05.10 in a concentration-dependent manner, indicating that membrane damage impairs fungal growth[1].
Murrayone (30-60 μg/mL; cultured on potato dextrose agar (PDA) for 3 days, followed by 24 h incubation on glass slides prior to staining) induces concentration-dependent ROS accumulation in the mycelia of *Botrytis cinerea* strain Bc05.10, indicating severe oxidative stress[1].
Murrayone (200 μg/mL; topical application; single dose) reduces the gray mold disease index in postharvest blueberry fruits to 58.33% over 5 days, demonstrating significant antifungal efficacy against Botrytis cinerea[1].
Murrayone (Compound 10) (5-50 μg/mL; incubated until control colonies cover 90% of the agar surface) moderately inhibits mycelial growth of Colletotrichum capsici, with an EC50 value of 24.9 μg/mL[2].
Murrayone (Compound 8) can significantly inhibit the abnormally elevated platelet aggregation induced by adenosine diphosphate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Botrytis cinerea Bc05.10
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Concentration:50, 100, 200 μg/mL
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Incubation Time:12 h after 48 h initial culture
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Result:Induced cell membrane damage.
Cell membrane damage detected by PI staining fluorescence.
Chemical Information
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No. CAS 19668-69-0
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Appearance Solid
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Peso molecular 258.27
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Fòrmula C15H14O4
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Color White to off-white
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SMILES
O=C1C=CC2=CC=C(OC)C(CC(C(C)=C)=O)=C2O1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
DMSO : 50 mg/mL (193.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (300 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhu W, et al. Murrayone: A Promising New Fungicide Destroying the Oxidative Homeostasis and Cell Membrane Integrity of Botrytis cinerea. J Agric Food Chem. 2026 May 27;74(20):15464-15476. [Content Brief]
[2]. Song PP, et al. Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives. Pest Manag Sci. 2017 Jan;73(1):94-101. [Content Brief]
[3]. Yang H, et al. [Coumarins from Leonurus japonicus and their anti-platelet aggregative activity]. Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8719 mL | 19.3596 mL | 38.7192 mL | 96.7979 mL |
| 5 mM | 0.7744 mL | 3.8719 mL | 7.7438 mL | 19.3596 mL | |
| 10 mM | 0.3872 mL | 1.9360 mL | 3.8719 mL | 9.6798 mL | |
| 15 mM | 0.2581 mL | 1.2906 mL | 2.5813 mL | 6.4532 mL | |
| 20 mM | 0.1936 mL | 0.9680 mL | 1.9360 mL | 4.8399 mL | |
| 25 mM | 0.1549 mL | 0.7744 mL | 1.5488 mL | 3.8719 mL | |
| 30 mM | 0.1291 mL | 0.6453 mL | 1.2906 mL | 3.2266 mL | |
| 40 mM | 0.0968 mL | 0.4840 mL | 0.9680 mL | 2.4199 mL | |
| 50 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9360 mL | |
| 60 mM | 0.0645 mL | 0.3227 mL | 0.6453 mL | 1.6133 mL | |
| 80 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2100 mL | |
| 100 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9680 mL |
Murrayone Related Classifications
HY-N2558 Related Classifications
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