2. Apoptosis Others
  3. Ferroptosis Fluorescent Dye
  4. Ferfluor-1

Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models.

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Ferfluor-1

Ferfluor-1 Chemical Structure

CAS No. : 3030473-59-4

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Ferfluor-1 Related Antibodies

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Description

Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models[1].

In Vitro

Ferfluor-1 potently inhibits ferroptosis in HT1080 fibrosarcoma cells with an EC50 of 57 nM, in OS-RC-2 renal carcinoma cells with an EC50 of 75 nM, and in SH-SY5Y neuroblastoma cells with an EC50 of 2.3 nM[1].
Ferfluor-1 (5 μM) does not inhibit Staurosporine (HY-15141)-induced apoptosis in SH-SY5Y neuroblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferfluor-1 Related Antibodies
In Vivo

Ferfluor-1 (10 mg/kg; i.v.; single administration) effectively alleviates cerebral ischemic damage in MCAO mice by inhibiting ferroptosis, as evidenced by reduced infarct volume, improved cerebral blood flow, and decreased markers of lipid peroxidation and ferroptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male)[1]
Dosage: 10 mg/kg
Administration: i.v.; single administration
Result: Substantially decreased cerebral infarction volume compared to the vehicle control.
Reduced the proportion of infarcted tissue compared to the vehicle control.
Improved blood flow in ischemic brain tissue compared to the vehicle control.
Significantly decreased PTGS2 gene expression in the lesioned hemisphere compared to the vehicle control.
Reduced malondialdehyde (MDA) levels in the lesioned hemisphere relative to the vehicle control.
Showed no obvious toxicity in major organs (heart, liver, spleen, lung, kidney) via histopathological staining.
Molecular Weight

288.41

Formula

C15H20N4S
CAS No.
SMILES

NC1=C(NC2CCCCC2)C=CC(C3=NN=C(C)S3)=C1
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Purity & Documentation
References
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Ferfluor-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferfluor-13030473-59-4Ferfluor1Ferfluor 1FerroptosisFluorescent Dyephospholipid peroxidationOS-RC-2 renal carcinoma cellsferroptosisphospholipid hydroperoxidesParkinson’s diseaseHT1080 fibrosarcoma cellsstrokeblood-brain barrierSH-SY5Y neuroblastoma cellsendoplasmic reticulumInhibitorinhibitorinhibit

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