2. Apoptosis Others
  3. Ferroptosis Fluorescent Dye
  4. Ferfluor-1

Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models.

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Ferfluor-1

Ferfluor-1 Chemical Structure

CAS No. : 3030473-59-4

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Ferfluor-1 Related Antibodies

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Description

Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models[1].

In Vitro

Ferfluor-1 potently inhibits ferroptosis in HT1080 fibrosarcoma cells with an EC50 of 57 nM, in OS-RC-2 renal carcinoma cells with an EC50 of 75 nM, and in SH-SY5Y neuroblastoma cells with an EC50 of 2.3 nM[1].
Ferfluor-1 (5 μM) does not inhibit Staurosporine (HY-15141)-induced apoptosis in SH-SY5Y neuroblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferfluor-1 Related Antibodies
In Vivo

Ferfluor-1 (10 mg/kg; i.v.; single administration) effectively alleviates cerebral ischemic damage in MCAO mice by inhibiting ferroptosis, as evidenced by reduced infarct volume, improved cerebral blood flow, and decreased markers of lipid peroxidation and ferroptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male)[1]
Dosage: 10 mg/kg
Administration: i.v.; single administration
Result: Substantially decreased cerebral infarction volume compared to the vehicle control.
Reduced the proportion of infarcted tissue compared to the vehicle control.
Improved blood flow in ischemic brain tissue compared to the vehicle control.
Significantly decreased PTGS2 gene expression in the lesioned hemisphere compared to the vehicle control.
Reduced malondialdehyde (MDA) levels in the lesioned hemisphere relative to the vehicle control.
Showed no obvious toxicity in major organs (heart, liver, spleen, lung, kidney) via histopathological staining.
Molecular Weight

288.41

Formula

C15H20N4S
CAS No.
Appearance

Solid

SMILES

NC1=C(NC2CCCCC2)C=CC(C3=NN=C(C)S3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (866.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4673 mL 17.3364 mL 34.6729 mL
5 mM 0.6935 mL 3.4673 mL 6.9346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.33%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4673 mL 17.3364 mL 34.6729 mL 86.6822 mL
5 mM 0.6935 mL 3.4673 mL 6.9346 mL 17.3364 mL
10 mM 0.3467 mL 1.7336 mL 3.4673 mL 8.6682 mL
15 mM 0.2312 mL 1.1558 mL 2.3115 mL 5.7788 mL
20 mM 0.1734 mL 0.8668 mL 1.7336 mL 4.3341 mL
25 mM 0.1387 mL 0.6935 mL 1.3869 mL 3.4673 mL
30 mM 0.1156 mL 0.5779 mL 1.1558 mL 2.8894 mL
40 mM 0.0867 mL 0.4334 mL 0.8668 mL 2.1671 mL
50 mM 0.0693 mL 0.3467 mL 0.6935 mL 1.7336 mL
60 mM 0.0578 mL 0.2889 mL 0.5779 mL 1.4447 mL
80 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0835 mL
100 mM 0.0347 mL 0.1734 mL 0.3467 mL 0.8668 mL
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Ferfluor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferfluor-13030473-59-4Ferfluor1Ferfluor 1FerroptosisFluorescent Dyephospholipid peroxidationOS-RC-2 renal carcinoma cellsferroptosisphospholipid hydroperoxidesParkinson’s diseaseHT1080 fibrosarcoma cellsstrokeblood-brain barrierSH-SY5Y neuroblastoma cellsendoplasmic reticulumInhibitorinhibitorinhibit

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