Ferroptosis-IN-6
Ferroptosis-IN-6 (compound 13) is a potent inhibitor of Ferroptosis with EC50 of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 1517780-59-4
- Formula: C15H17NO
- Molecular Weight:227.30
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | EC50 |
25.5 nM
Compound: 13
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Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-1080 cells assessed as inhibition of ferroptosis incubated for 24 hrs by CCK-8 assay
Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-1080 cells assessed as inhibition of ferroptosis incubated for 24 hrs by CCK-8 assay
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[PMID: 38056303] |
Chemical Information
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CAS No. 1517780-59-4
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Appearance Solid
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Molecular Weight 227.30
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Formula C15H17NO
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Color Brown to dark brown
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SMILES
OC1=C(C)C=CC=C1NCC2=CC=C(C)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (109.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3995 mL | 21.9974 mL | 43.9947 mL | 109.9868 mL |
| 5 mM | 0.8799 mL | 4.3995 mL | 8.7989 mL | 21.9974 mL | |
| 10 mM | 0.4399 mL | 2.1997 mL | 4.3995 mL | 10.9987 mL | |
| 15 mM | 0.2933 mL | 1.4665 mL | 2.9330 mL | 7.3325 mL | |
| 20 mM | 0.2200 mL | 1.0999 mL | 2.1997 mL | 5.4993 mL | |
| 25 mM | 0.1760 mL | 0.8799 mL | 1.7598 mL | 4.3995 mL | |
| 30 mM | 0.1466 mL | 0.7332 mL | 1.4665 mL | 3.6662 mL | |
| 40 mM | 0.1100 mL | 0.5499 mL | 1.0999 mL | 2.7497 mL | |
| 50 mM | 0.0880 mL | 0.4399 mL | 0.8799 mL | 2.1997 mL | |
| 60 mM | 0.0733 mL | 0.3666 mL | 0.7332 mL | 1.8331 mL | |
| 80 mM | 0.0550 mL | 0.2750 mL | 0.5499 mL | 1.3748 mL | |
| 100 mM | 0.0440 mL | 0.2200 mL | 0.4399 mL | 1.0999 mL |
Ferroptosis-IN-6 Related Classifications
HY-163074 Related Classifications
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