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Cat. No.: HY-D3235

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FDOCl-22

FDOCl-22 is a HOCl-responsive probe. FDOCl-22 reacts with hypochlorous acid to significantly enhance near-infrared emission and absorption signals, enabling the detection of HOCl levels associated with reagent-induced acute kidney injury. FDOCl-22 can be used in studies related to reagent-induced acute kidney injury.

For research use only. We do not sell to patients.

CAS No.: 2540586-21-6
Formula: C₂₅H₃₆N₄O₅S
Molecular Weight:504.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FDOCl-22 Chemical Structure

CAS No.: 2540586-21-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

FDOCl-22 (12-24 h) is non-toxic to RAW264.7 macrophages after 12 h or 24 h of exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2540586-21-6
Molecular Weight 504.64
Formula C₂₅H₃₆N₄O₅S
SMILES

CN(C)C1=CC=C(N(C(NCCOCCOCCOCCO)=O)C(C=CC(N(C)C)=C2)=C2S3)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Nephrotoxicity Study
This protocol assesses nephrotoxicity by combining functional kidney injury readouts, urinary/tissue injury biomarkers, and renal histopathology. Serum creatinine and BUN reflect impaired kidney function, while KIM-1, NGAL, clusterin, osteopontin, IL-18, cystatin C, nephrin, Oat5, urinary protein, glucose, and alkaline phosphatase have been used to detect tubular injury in cisplatin-, gentamicin-, and acetaminophen-induced nephrotoxicity models.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu L, et al. Dual-Modality Detection of Early-Stage Drug-Induced Acute Kidney Injury by an Activatable Probe. ACS Sens. 2020;5(8):2457-2466. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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