FR260330
FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model.
For research use only. We do not sell to patients.
- CAS No.: 442198-67-6
- Formula: C29H28ClF3N6O4
- Molecular Weight:617.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
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iNOS |
Chemical Information
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CAS No. 442198-67-6
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Molecular Weight 617.02
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Formula C29H28ClF3N6O4
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SMILES
O=C(N1CCC(OC2=NC=NC(C(F)(F)F)=C2)CC1)CNC([C@@H](NC(/C=C/C3=CC=C(Cl)C=C3)=O)CC4=CC=CC=N4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)