Galactose 1-phosphate-13C potassium
Based on 1 Customer Validation
Galactose 1-phosphate-13C potassium is the 13C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt acts as a competitive substrate inhibitor of galactose-1-phosphate uridylyltransferase (GALT). Galactose 1-phosphate Potassium salt is a competitive inhibitor of Phosphoglucomutase, yet the rate at which this enzyme converts Galactose 1-phosphate to Galactose-6-phosphate is 400 times slower than the rate of converting Glucose-1-phosphate. Galactose 1-phosphate Potassium salt can be used in studies related to Saccharomyces cerevisiae infection and type I galactosemia.
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- Purity : 98.8%
- CAS No.: 478518-78-4
- 화학식: C513CH11K2O9P
- 분자량:337.31
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
제품 설명
IC50 & Target
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Human Endogenous Metabolite |
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 478518-78-4
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Unlabeled CAS 19046-60-7
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Appearance Solid
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분자량 337.31
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화학식 C513CH11K2O9P
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Color White to off-white
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SMILES
O=P(O[K])(O[K])O[13C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
In Vitro:
H2O : 125 mg/mL (370.58 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. metabolism pathwaysMcCorvie TJ, et al. The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase. IUBMB Life. 2011 Sep;63(9):694-700. [Content Brief]
[2]. Machado, C. M., et al., (2017). The galactose-induced decrease in phosphate levels leads to toxicity in yeast models of galactosemia. Biochimica et biophysica acta. Molecular basis of disease, 1863(6), 1403–1409. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9646 mL | 14.8232 mL | 29.6463 mL | 74.1158 mL |
| 5 mM | 0.5929 mL | 2.9646 mL | 5.9293 mL | 14.8232 mL | |
| 10 mM | 0.2965 mL | 1.4823 mL | 2.9646 mL | 7.4116 mL | |
| 15 mM | 0.1976 mL | 0.9882 mL | 1.9764 mL | 4.9411 mL | |
| 20 mM | 0.1482 mL | 0.7412 mL | 1.4823 mL | 3.7058 mL | |
| 25 mM | 0.1186 mL | 0.5929 mL | 1.1859 mL | 2.9646 mL | |
| 30 mM | 0.0988 mL | 0.4941 mL | 0.9882 mL | 2.4705 mL | |
| 40 mM | 0.0741 mL | 0.3706 mL | 0.7412 mL | 1.8529 mL | |
| 50 mM | 0.0593 mL | 0.2965 mL | 0.5929 mL | 1.4823 mL | |
| 60 mM | 0.0494 mL | 0.2471 mL | 0.4941 mL | 1.2353 mL | |
| 80 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.9264 mL | |
| 100 mM | 0.0296 mL | 0.1482 mL | 0.2965 mL | 0.7412 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Galactose 1-phosphate-13C potassium Related Classifications
HY-113143AS Related Classifications
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