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Cat. No.: HY-186234

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α-Synuclein aggregate binder 3

α-Synuclein aggregate binder 3 is a probe for α-synuclein aggregates. The K_i value of α-Synuclein aggregate binder 3 for binding to sonicated α-synuclein fibrils is 0.8 nM. α-Synuclein aggregate binder 3 can be used for α-synuclein imaging, as well as for detecting disorders associated with α-synuclein aggregation, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

For research use only. We do not sell to patients.

CAS No.: 2648041-95-4
Formula: C₁₅H₁₃FN₄
Molecular Weight:268.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Synuclein aggregate binder 3 Chemical Structure

CAS No.: 2648041-95-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

α-synuclein Aggregation

All α-synuclein Isoforms :

In Vitro

α-Synuclein aggregate binder 3 (compound 3) binds to sonicated α-synuclein fibrils with a K_i of 0.95 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2648041-95-4
Molecular Weight 268.29
Formula C₁₅H₁₃FN₄
SMILES

FC1=NC=CC(C2=CC(C3=CC=C(NC)C=C3)=NN2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1].
Armin Giese, et al. Novel compounds for the diagnosis, treatment and prevention of diseases associated with the aggregation of alpha-synuclein. WO2021099518A1. 2020-11-19.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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