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Cat. No.: HY-162721

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Anticancer agent 242

Anticancer agent 242 (7) possesses anticancer activity in A2780 (IC₅₀ = 0.24 μM, ovarian adenocarcinoma), A2780cis (IC₅₀ = 0.45 μM, resistant derivative of A2780), CCD18Co (IC₅₀ = 0.59 μM, non-malignant human fibroblasts), A549 (IC₅₀ = 0.32 μM, lung carcinoma), HT29 (IC₅₀ = 0.26 μM, colorectal adenocarcinoma), and MCF7 (IC₅₀ = 0.55 μM, breast adenocarcinoma).

For research use only. We do not sell to patients.

Formula: C₅₉H₇₂ClF₃N₆O₅S₂
Molecular Weight:1101.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 242 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.24 μM Compound: 7	Cytotoxicity against human A2780 cells incubated for 72 hrs by SRB assay Cytotoxicity against human A2780 cells incubated for 72 hrs by SRB assay	[PMID: 38996651]
A2780cis	IC₅₀	0.45 μM Compound: 7	Cytotoxicity against human A2780cis cells incubated for 72 hrs by SRB assay Cytotoxicity against human A2780cis cells incubated for 72 hrs by SRB assay	[PMID: 38996651]
A549	IC₅₀	0.59 μM Compound: 7	Cytotoxicity against human A549 cells incubated for 72 hrs by SRB assay Cytotoxicity against human A549 cells incubated for 72 hrs by SRB assay	[PMID: 38996651]
CCD-18Co	IC₅₀	0.55 μM Compound: 7	Cytotoxicity against human CCD-18Co cells incubated for 72 hrs by SRB assay Cytotoxicity against human CCD-18Co cells incubated for 72 hrs by SRB assay	[PMID: 38996651]
HT-29	IC₅₀	0.32 μM Compound: 7	Cytotoxicity against human HT-29 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HT-29 cells incubated for 72 hrs by SRB assay	[PMID: 38996651]
MCF7	IC₅₀	0.26 μM Compound: 7	Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay	[PMID: 38996651]

Chemical Information

Molecular Weight 1101.82
Formula C₅₉H₇₂ClF₃N₆O₅S₂
SMILES

FC1=C(F)C(SCCC2=CC=C(C(N3CCN(C(C4=CC=CC=C4C5=C(C=C/6)C(OC7=C5C=CC(N(CC)CC)=C7)=CC6=[N+](CC)\CC)=O)CC3)=O)C=C2)=C(F)C(NC8CCCCCCCCCCC8)=C1S(=O)(N)=O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Niels V Heise, et al. Dehydroabietylamine-substituted trifluorobenzene sulfonamide rhodamine B hybrids as anticancer agents overcoming drug resistance. Eur J Med Chem. 2024 Jul 10:276:116667. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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