ProAlk01
ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.
For research use only. We do not sell to patients.
- CAS No.: 1296670-84-2
- Formula: C31H28Cl2N2O4
- Molecular Weight:563.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.7 nM
Compound: BDA 2
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 30620194] |
ProAlk01 (1-100 pM) exhibits potent in vitro cytotoxic activity across a broad panel of solid tumor cell lines with IC50 values in the 1-100 pM range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1296670-84-2
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Molecular Weight 563.47
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Formula C31H28Cl2N2O4
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SMILES
O=C(N1C[C@H](C2=C1C=C(C3=C2C=CC=C3)O)CCl)CCCC(N4C[C@H](C5=C4C=C(C6=C5C=CC=C6)O)CCl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ProAlk01 Related Classifications
HY-183623 Related Classifications
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