8-OAc
8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines.
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- No. CAS: 2550395-87-2
- Fòrmula: C24H34N2O4S
- Peso molecular:446.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
8-OAc (5-100 μM; 24 h) could preferentially target cancer cells for the initiation of cell death pathways, while having minimal effects on viability of non-cancer cells. 8-OAc can induce ROS production, leading to cell death in liver cancer cells[1].
8-OAc is able to achieve a mitohormetic effect in C. elegans and prolong longevity in adult worms. 8-OAc requires HSF1 mediate heat shock response (HSR) pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 liver carcinoma cells and BJ fibroblast non-cancer cells
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Concentration:5 μM, 10 μM, 50 μM, 100 μM
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Incubation Time:24 h
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Result:Inhibited Huh-7 and BJ cells with IC50 of 95.97 μM and 248.15 μM, respectively.
Chemical Information
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No. CAS 2550395-87-2
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Peso molecular 446.60
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Fòrmula C24H34N2O4S
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SMILES
O=C(NCCC(/C=C\C[C@H](OC(C)=O)C(C)(C)C1=NC(C/C=C\CC=C)=CS1)=C)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-OAc Related Classifications
HY-162515 Related Classifications
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