Anticancer agent 136
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent.
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- No. CAS: 3049419-74-8
- Fòrmula: C40H50N6O8
- Peso molecular:742.86
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NHDF | IC50 |
3.38 μM
Compound: 22
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Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
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[PMID: 37210951] |
| PC-3 | IC50 |
1.11 μM
Compound: 22
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Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
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[PMID: 37210951] |
| SK-BR-3 | IC50 |
1.16 μM
Compound: 22
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Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
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[PMID: 37210951] |
| SK-OV-3 | IC50 |
1.08 μM
Compound: 22
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Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
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[PMID: 37210951] |
Chemical Information
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No. CAS 3049419-74-8
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Peso molecular 742.86
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Fòrmula C40H50N6O8
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SMILES
O=C1C(NCC2=CN(C/C=C/C3=CC=CC=C3)N=N2)=C4C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C4)=O)=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 136 Related Classifications
HY-149367 Related Classifications
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