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Referencia número: HY-184302

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Apoptosis inducer 62

Apoptosis inducer 62 is an apoptosis inducer that reduces the expression levels of anti-apoptotic proteins Bcl-2 and Bcl-xL. Apoptosis inducer 62 induces ROS accumulation, mitochondrial membrane potential depolarization, DNA damage, cell cycle arrest. Apoptosis inducer 62 exhibits activity in colorectal tumor xenograft models. Apoptosis inducer 62 can be used for research related to colorectal cancer.

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Fòrmula: C₃₆H₄₂F₃NO₃
Peso molecular:593.72

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apoptosis inducer 62 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

Bcl-xL

Bcl-2

Ver todos los productos específicos de isoformas Bcl-2 Family :

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

Apoptosis inducer 62 (Compound 28a) (1 μM; 72 h) potently inhibits the proliferation of HCT116, MIA-PaCa-2, HepG-2 and HeLa cancer cells, with IC₅₀ values of 0.34, 0.6, 0.71 and 0.77 μM^[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly increases intracellular ROS levels in HCT116 cells in a concentration-dependent manner in vitro^[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces mitochondrial membrane potential depolarization in HCT116 cells in a concentration-dependent manner in vitro^[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly induces apoptosis in HCT116 cells in a concentration-dependent manner in vitro^[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner in vitro^[1].
Apoptosis inducer 62 (0.25-1 μM; 24 h) regulates the expression of apoptosis-related proteins and DNA damage-related proteins (Bcl-xL, Bcl-2, Cyt c, γ-H2AX) in HCT116 cells, and promotes cell apoptosis and DNA damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.5, 1 and 2 μM
Incubation Time:

48 h
Result:

Significantly induced apoptosis in HCT116 cells in a concentration-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.5, 1 and 2 μM
Incubation Time:

48 h
Result:

Significantly induced S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.25, 0.5 and 1 μM
Incubation Time:

24 h
Result:

Decreased Bcl-xL and Bcl-2.
Increased Cyt c and γ-H2AX.

In Vivo

Apoptosis inducer 62 (Compound 28a) (2 mg/kg; i.p.; daily; 14 days) exhibits potent in vivo antitumor efficacy in HCT116 colorectal cancer xenografts, with a 47.9% tumor growth inhibition rate, and no associated body weight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (female, 5 weeks old)^[1]
Dosage:

2 mg/kg
Administration:

i.p.; daily; 14 days
Result:

Achieved a tumor growth inhibition rate (TGI) of 47.9%.
Significantly suppressed tumor volume and tumor weight compared to the control group.
Caused no obvious body weight loss during the 14-day treatment period.

Chemical Information

Peso molecular 593.72
Fòrmula C₃₆H₄₂F₃NO₃
SMILES

O=C1C=C2[C@]3(C)CC[C@@]4(C)[C@]5([H])C[C@@](C(N)=O)(CC6=CC=C(C(F)(F)F)C=C6)CC[C@]5(C)CC[C@]4(C)C3=CC=C2C(C)=C1O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Shang FF, et al.. Palladium-catalyzed C(sp)-H arylation of celastrol: synthesis and pharmacological evaluation of C-21/28 arylated derivatives. Bioorganic chemistry. 2026 May 27;180:110053. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Apoptosis inducer 62

Ver todos los productos específicos de isoformas Bcl-2 Family

Ver todos los productos específicos de isoformas DNA/RNA Synthesis