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Referencia número: HY-202191

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(1-Amino-1-phosphonooctyl)phosphonic acid

Name: (1-Amino-1-phosphonooctyl)phosphonic acid
Brand: MedChemExpress
SKU: HY-202191
Price: 350.00 USD
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(1-Amino-1-phosphonooctyl)phosphonic acid is a selective acid sphingomyelinase (aSMase) inhibitor with an IC₅₀ of 40 nM against rat aSMase. (1-Amino-1-phosphonooctyl)phosphonic acid blocks the hydrolysis of sphingomyelin to ceramide and shows no significant inhibition of Mg²⁺-dependent neutral sphingomyelinase (nSMase).

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Pureza : 98.5%
No. CAS: 15049-89-5
Fòrmula: C₈H₂₁NO₆P₂
Peso molecular:289.20

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(1-Amino-1-phosphonooctyl)phosphonic acid Chemical Structure

No. CAS: 15049-89-5

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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

Acid sphingomyelinase (aSMase)

40 nM (IC₅₀)

Ver todos los productos específicos de isoformas Phospholipase :

In Vitro

Lipid Metabolism

(1-Amino-1-phosphonooctyl)phosphonic acid (compound 7b) (20 µM for 3 h) inhibits rat brain aSMase by 93% in a single-point screen^[1].
(1-Amino-1-phosphonooctyl)phosphonic acid (Up to 100 µM) does not substantially inhibit Mg²⁺-dependent nSMase (IC₅₀ >100 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 15049-89-5
Appearance Solid
Peso molecular 289.20
Fòrmula C₈H₂₁NO₆P₂
Color Yellow to orange
SMILES

O=P(O)(O)C(N)(CCCCCCC)P(=O)(O)O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Int Arch Allergy Immunol

Acid Sphingomyelinase-Ceramide Axis Modulation Is Associated with Thymic Stromal Lymphopoietin Release and Epithelial Barrier Dysfunction in an in vitro Type 2 Inflammation Model Relevant to Pediatric Rhinitis. [Abstract]

2026 Aug 3:1. PMID: 42545914

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Roth AG, et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew Chem Int Ed Engl. 2009;48(41):7560-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

(1-Amino-1-phosphonooctyl)phosphonic acid

1 Cited Publications

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Actividad biológica
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(1-Amino-1-phosphonooctyl)phosphonic acid

Publications Citing Use of MedChemExpress (MCE) (1-Amino-1-phosphonooctyl)phosphonic acid

Ver todos los productos específicos de isoformas Phospholipase