Arcopilin A
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively.
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- Fòrmula: C22H27NO4
- Peso molecular:369.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB 3-1 | IC50 |
8.9 μg/mL
Compound: 1; Acp A
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Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
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[PMID: 39141525] |
| L929 | IC50 |
14 μg/mL
Compound: 1; Acp A
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Cytotoxicity against mouse L929 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
Cytotoxicity against mouse L929 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
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[PMID: 39141525] |
Arcopilin A disruptes preformed biofilms by approximately 50-60% in the concentration range of 15.6-250 μg/mL, and can also inhibit the growth of Staphylococcus aureus at concentrations as low as 3.9 and 7.8 μg/mL[1].
Arcopilin A has an MIC value of 66.7 μg/mL against B.subtilis DSM 10, S.aureus DSM 346, S.pombe DSM70572, C.albicans DSM 1665, and M.hiemalis DSM 2656, and an MIC value of 31.3 μg/mL against S.aureus DSM 1104[1].
Arcopilin A (3.9-31.1 μg/mL) reduces biofilm metabolic activity in a dose-dependent manner[1].
Arcopilin A (2-7.8 μg/mL) inhibits the growth of Staphylococcus aureus DSM 1104 planktonic cells[1].
Arcopilin A (3.9-7.8 μg/mL, 24 h) when used with GM (HY-K1050) and Vac (HY-B0671) have a synergistic effect on Staphylococcus aureus DSM 1104 planktonic cells. The MIC values of the established antibiotics were reduced from 15.6 to 0.13 μg/mL and from 2 to 0.065 μg/mL respectively. The combined treatment significantly increased the potency of GM (HY-K1050) and Vac (HY-B0671) by 115-fold and 31-fold, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 369.45
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Fòrmula C22H27NO4
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SMILES
CC([C@@H](C[C@H](C[C@@H](C(C1=C(/C(NC1=O)=C/C2=CC=CC=C2)O)=O)C)C)C)=O
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Structure Classification
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Initial Source
Arcopilus navicularis CCF 3252T
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arcopilin A Related Classifications
HY-N13196 Related Classifications
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