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Referencia número: HY-144637

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Autophagy inducer 2

Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC₅₀ value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer.

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No. CAS: 2684238-37-5
Fòrmula: C₄₁H₅₈N₆O
Peso molecular:650.94

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Autophagy inducer 2 Chemical Structure

No. CAS: 2684238-37-5

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.36 μM Compound: 11i	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]
Bel-7402	IC₅₀	6.81 μM Compound: 11i	Antiproliferative activity against human Bel-7402 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human Bel-7402 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]
HT-29	IC₅₀	1.6 μM Compound: 11i	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]
L02	IC₅₀	4.68 μM Compound: 11i	Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]
MCF7	IC₅₀	1.31 μM Compound: 11i	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]
PC-3	IC₅₀	4.98 μM Compound: 11i	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 35290844]

Chemical Information

No. CAS 2684238-37-5
Peso molecular 650.94
Fòrmula C₄₁H₅₈N₆O
SMILES

C[C@]12[C@@]([C@]3(C(C4=CC5=NC=CN=C5C(C)=C4C=C3)=CC1)C)(CC[C@@]6([C@@]2([H])C[C@@](C)(CC6)NC(N7CCN(C8CCN(CC8)C)CC7)=O)C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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