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Referencia número: HY-128616

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BNBC

BNBC is a human STING-specific agonist. BNBC activates STING-IRF3 signaling, induces the expression of inflammatory cytokines such as type I/III interferons, and promotes dendritic cell maturation and the establishment of an antiviral state. BNBC can be used for research on STING-mediated innate immunity, dendritic cell function, and viral infection.

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No. CAS: 55171-63-6
Fòrmula: C₁₈H₁₂BrNO₃
Peso molecular:370.20

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Please store the product under the recommended conditions in the Certificate of Analysis.

BNBC Chemical Structure

No. CAS: 55171-63-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

In Vitro

Innate ImmunityCytokines & ChemokinesViral InfectionAdaptive ImmunityCytokines and Chemokines

Innate Immunity

Cytokines & Chemokines

BNBC (up to 200 µM; 4 h) concentration-dependently activates ISG54 promoter-driven luciferase expression in HepAD38/cGAS-STING/ISG54Luc and HepG2/STING/ISG54Luc cells, but not in STINGΔC cells; BNBC shows no obvious cytotoxicity up to 200 μM, suggesting that it activates the cGAS-STING pathway, with the site of action possibly downstream of cGAS, at STING, or upstream^[1].
BNBC (6 h) induces IFN-β, IL-29, and TNF-α mRNA expression in a concentration-dependent manner in HepG2/STING cells, but has no effect on parental HepG2, HepG2/STINGΔC, or HepG2/mSTING cells^[1].
BNBC (6-18 h) induces IFN-β, IL-28A, and IL-6 mRNA expression and IFN-β secretion in THF cells; STING knockout completely blocks BNBC-induced IFN-β mRNA expression, whereas TRIF or IPS-1/MAVS knockout does not^[1].

Innate Immunity

NBC (100 μM; 2 h) induces human STING nuclear translocation, IRF3 phosphorylation, and IRF3 nuclear translocation; its STING translocation is independent of the CTD, but IRF3 activation depends on the STING CTD^[1].
BNBC (50 μM; 4-8 h) induces an innate proinflammatory cytokine gene expression profile consistent with STING activation in THF cells and upregulates components related to PRR and interferon signaling^[1].
BNBC (6 h) induces type I/III IFN expression and, to a lesser extent, TNF-α expression in human PBMCs^[1].

Viral Infection

BNBC (pretreatment for 8 h) reduces DENV, YFV, and ZIKV RNA levels in THF cells in a concentration-dependent manner, with maximum reductions of approximately 90-, 150-, and 800-fold, respectively^[1].

Innate Immunity

Adaptive Immunity

Cytokines and Chemokines

BNBC (100 μM; 6 h) induces IFN-β, IL-29, TNF-α, and IL-6 mRNA expression in human PBMC-derived dendritic cells; BNBC (50 μM; 48 h) induces CD80 expression, suggesting that it promotes
dendritic cell maturation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 55171-63-6
Peso molecular 370.20
Fòrmula C₁₈H₁₂BrNO₃
SMILES

O=C(NC1=CC=CC=2C=CC=CC21)C=3C=C4OCOC4=CC3Br
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang X, et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist. ACS Infect Dis. 2019 Jul 12;5(7):1139-1149.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BNBC

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BNBC Related Classifications

HY-128616 Related Classifications

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