Brasimarin B
Brasimarin B is a 4-phenylcoumarin compound found in the stem bark of Calophyllum brasiliense. Brasimarin B inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells.
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- No. CAS: 514214-46-1
- Fòrmula: C25H26O6
- Peso molecular:422.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Raji | IC50 |
342 molar ratio
Compound: 3
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Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
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[PMID: 12662094] |
Brasimarin B (Compound 3) (0.32-32 nmol; 48 h) inhibits TPA (HY-18739) (20 ng/mL)-induced EBV-EA activation in Raji cells with an IC50 of 10.944 nmol, completely blocking activation at the highest tested concentration without significant cell viability loss[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 514214-46-1
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Peso molecular 422.47
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Fòrmula C25H26O6
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SMILES
CCC(C)C(C1=C(O)C(CC(O2)C(C)(O)C)=C2C(C(C3=CC=CC=C3)=C4)=C1OC4=O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Ito C, et al. Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins. J Nat Prod. 2003;66(3):368-371. [Content Brief]
[2]. César GZ, et al. Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico. Fitoterapia. 2011;82(7):1027-1034. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brasimarin B Related Classifications
HY-N19721 Related Classifications
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