CL 218872
Based on 1 Customer Validation
CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.25%
- No. CAS: 66548-69-4
- Fòrmula: C13H9F3N4
- Peso molecular:278.24
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
CL 218872 (5-20 mg/kg; p.o.) reduces locomotor activity, head-dipping, and rearing in rats, with sedative effects reversed by Flumazenil (HY-B0009)[3].
CL 218872 (20-40 mg/kg; s.c.) antagonizes Diazepam-induced loss of righting reflex in mice[4].
CL 218872 (5-20 mg/kg; i.p.) impairs place learning in rats, increasing swim path length and reducing quadrant bias in probe trials[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD Sprague-Dawley rats (200-300 g, sex: male, weight: 200-300 g)[2]
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Dosage:5 mg/kg, 20 mg/kg
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Administration:Oral administration
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Result:Reduced locomotor activity and impaired motor coordination.
Chemical Information
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No. CAS 66548-69-4
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Appearance Solid
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Peso molecular 278.24
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Fòrmula C13H9F3N4
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Color Light yellow to brown
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SMILES
FC(C1=CC(C2=NN3C(C=C2)=NN=C3C)=CC=C1)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 16.67 mg/mL (59.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10(5):825-30. [Content Brief]
[2]. Oakley NR, et al. The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents. Neuropharmacology. 1984 Jul;23(7A):797-802. [Content Brief]
[3]. File SE, et al. The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists. Psychopharmacology (Berl). 1985;85(3):295-300. [Content Brief]
[4]. Gee KW, et al. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28;32(9):1037-40. [Content Brief]
[5]. McNamara RK, et al. Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology (Berl). 1992;107(2-3):347-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5940 mL | 17.9701 mL | 35.9402 mL | 89.8505 mL |
| 5 mM | 0.7188 mL | 3.5940 mL | 7.1880 mL | 17.9701 mL | |
| 10 mM | 0.3594 mL | 1.7970 mL | 3.5940 mL | 8.9850 mL | |
| 15 mM | 0.2396 mL | 1.1980 mL | 2.3960 mL | 5.9900 mL | |
| 20 mM | 0.1797 mL | 0.8985 mL | 1.7970 mL | 4.4925 mL | |
| 25 mM | 0.1438 mL | 0.7188 mL | 1.4376 mL | 3.5940 mL | |
| 30 mM | 0.1198 mL | 0.5990 mL | 1.1980 mL | 2.9950 mL | |
| 40 mM | 0.0899 mL | 0.4493 mL | 0.8985 mL | 2.2463 mL | |
| 50 mM | 0.0719 mL | 0.3594 mL | 0.7188 mL | 1.7970 mL |
CL 218872 Related Classifications
HY-103505 Related Classifications
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