COMT-IN-1
COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice.
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- No. CAS: 2987884-27-3
- Fòrmula: C24H18FN3O6
- Peso molecular:463.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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COMT 0.37 μM (IC50) |
MAO-A 95.58 μM (IC50) |
MAO-B 58.82 μM (IC50) |
Chemical Information
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No. CAS 2987884-27-3
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Peso molecular 463.41
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Fòrmula C24H18FN3O6
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SMILES
OC1=C([N+]([O-])=O)C=C(/C=C(C(NCC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)=O)\C#N)C=C1O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COMT-IN-1 Related Classifications
HY-162760 Related Classifications
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