Dapiprazole
Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.
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- No. CAS: 72822-12-9
- Fòrmula: C19H27N5
- Peso molecular:325.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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α1-adrenergic receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model[1]
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Dosage:5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
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Administration:Intraperitoneal injection or intracerebroventricular administration, once
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Result:Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
Chemical Information
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No. CAS 72822-12-9
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Peso molecular 325.45
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Fòrmula C19H27N5
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SMILES
CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [Content Brief]
[2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [Content Brief]
[3]. Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dapiprazole Related Classifications
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