DBPR110
DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A.
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- No. CAS: 1310694-75-7
- Fòrmula: C50H48N6O4S2
- Peso molecular:861.08
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>50 μM
Compound: 27a
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Cytotoxicity against human HuH7 cells assessed as reduction in cell viability by MTS assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability by MTS assay
|
[PMID: 30772607] |
Chemical Information
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No. CAS 1310694-75-7
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Peso molecular 861.08
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Fòrmula C50H48N6O4S2
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SMILES
O=C(C1CC1)N[C@H](C2=CC=CC=C2)C(N3[C@H](C4=NC=C(C5=CC=C(C6=CC=C(C7=CN=C([C@H]8N(CCC8)C([C@@H](C9=CC=CC=C9)NC(C%10CC%10)=O)=O)S7)C=C6)C=C5)S4)CCC3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DBPR110 Related Classifications
HY-114216 Related Classifications
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