Eleclazine
Based on 2 publication(s) in Google Scholar
Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias.
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- Pureza: 98.0%
- No. CAS: 1443211-72-0
- Fòrmula: C21H16F3N3O3
- Peso molecular:415.37
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-12533
Disopyramide
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HY-101433
N-Acetylprocainamide hydrochloride
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HY-17429
Flecainide acetate
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HY-101433R
N-Acetylprocainamide hydrochloride (Standard)
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HY-17497
Acebutolol
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HY-Z18056
Norpropranolol hydrochloride
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HY-12533R
Disopyramide (Standard)
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HY-101245
Pilsicainide hydrochloride
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HY-17429R
Flecainide acetate (Standard)
Publications Citing Use of MedChemExpress (MCE) Eleclazine
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Actividad biológica
Chemical Information
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No. CAS 1443211-72-0
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Appearance Solid
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Peso molecular 415.37
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Fòrmula C21H16F3N3O3
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Color Light yellow to yellow
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SMILES
O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13
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Synonyms
GS-6615
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Philos Trans R Soc Lond B Biol Sci
Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation. [Abstract]2023 Jun 19;378(1879):20220163. PMID: 37122215 -
Am J Transl Res
Homocysteine-induced electrical remodeling via the mediation of IP3R1/Nav1.5 signaling pathway. [Abstract]2020 Jul 15;12(7):3822-3841. PMID: 32774738
Solvente y solubilidad
DMF : 20 mg/mL (48.15 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bacic D, et al. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 Mar;14(3):448-454. [Content Brief]
[2]. Potet F, Egecioglu DE, Burridge PW, George AL Jr. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98(5):540-547. [Content Brief]
[3]. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.4075 mL | 12.0375 mL | 24.0749 mL | 60.1873 mL |
| 5 mM | 0.4815 mL | 2.4075 mL | 4.8150 mL | 12.0375 mL | |
| 10 mM | 0.2407 mL | 1.2037 mL | 2.4075 mL | 6.0187 mL | |
| 15 mM | 0.1605 mL | 0.8025 mL | 1.6050 mL | 4.0125 mL | |
| 20 mM | 0.1204 mL | 0.6019 mL | 1.2037 mL | 3.0094 mL | |
| 25 mM | 0.0963 mL | 0.4815 mL | 0.9630 mL | 2.4075 mL | |
| 30 mM | 0.0802 mL | 0.4012 mL | 0.8025 mL | 2.0062 mL | |
| 40 mM | 0.0602 mL | 0.3009 mL | 0.6019 mL | 1.5047 mL |
Eleclazine Related Classifications
HY-16738 Related Classifications
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