Fuberidazole
Based on 1 Customer Validation
Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea.
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- Pureza: 99.90%
- No. CAS: 3878-19-1
- Fòrmula: C11H8N2O
- Peso molecular:184.20
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Antifungal Compound Library
HY-L048
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Human Metabolite Library
HY-L123
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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HY-L205
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HY-L215
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HY-L002
Actividad biológica
B. cinerea[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
102.53 μM
Compound: 4a
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 28505536] |
| MCF7 | IC50 |
105.64 μM
Compound: 4a
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 28505536] |
| MCF7 | IC50 |
21.5 μg/mL
Compound: 3a
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Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
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[PMID: 24576797] |
Fuberidazole (FBZ) (10 μM) shows pKa shifts of 1.4 units in the present of CB8 (100 μM)[1].
Fuberidazole (10-200 μM; 72 h) exhibits an increasing growth inhibition rate on B. cinerea. And the CB7/CB8-bound Fuberidazole inhibits the growth of B. cinerea at least three times than Fuberidazole alone[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3878-19-1
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Appearance Solid
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Peso molecular 184.20
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Fòrmula C11H8N2O
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Color Off-white to light yellow
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SMILES
C1(C2=CC=CO2)=NC3=CC=CC=C3N1
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Synonyms
BAY 33172; Furidazole
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (678.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 12.5 mg/mL (67.86 mM); Clear solution
This protocol yields a clear solution of ≥ 12.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (125.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (731 KB)
- English - EN (731 KB)
- Français - FR (731 KB)
- Deutsch - DE (731 KB)
- Norwegian - NO (731 KB)
- Español - ES (731 KB)
- Swedish - SV (731 KB)
- Italian - IT (731 KB)
- Korean - KR (731 KB)
- Portuguese - PT (731 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4289 mL | 27.1444 mL | 54.2888 mL | 135.7220 mL |
| 5 mM | 1.0858 mL | 5.4289 mL | 10.8578 mL | 27.1444 mL | |
| 10 mM | 0.5429 mL | 2.7144 mL | 5.4289 mL | 13.5722 mL | |
| 15 mM | 0.3619 mL | 1.8096 mL | 3.6193 mL | 9.0481 mL | |
| 20 mM | 0.2714 mL | 1.3572 mL | 2.7144 mL | 6.7861 mL | |
| 25 mM | 0.2172 mL | 1.0858 mL | 2.1716 mL | 5.4289 mL | |
| 30 mM | 0.1810 mL | 0.9048 mL | 1.8096 mL | 4.5241 mL | |
| 40 mM | 0.1357 mL | 0.6786 mL | 1.3572 mL | 3.3931 mL | |
| 50 mM | 0.1086 mL | 0.5429 mL | 1.0858 mL | 2.7144 mL | |
| 60 mM | 0.0905 mL | 0.4524 mL | 0.9048 mL | 2.2620 mL | |
| 80 mM | 0.0679 mL | 0.3393 mL | 0.6786 mL | 1.6965 mL | |
| 100 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.3572 mL |
Fuberidazole Related Classifications
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