ANKS1A - ankyrin repeat and sterile alpha motif domain containing 1A Gene

Also Known as ANKS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23294

About ANKS1A

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,889,255-35,097,990 (from NCBI)

This gene has 7 transcripts (splice variants), 277 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 8.5), testis (RPKM 6.9) and 25 other tissues.

Summary

Predicted to enable Ephrin Receptor binding activity. Predicted to be involved in Ephrin Receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of Ephrin Receptor signaling pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANKS1A Products (1)

mRNA Protein Name
NM_015245.3 NP_056060.2 ankyrin repeat and SAM domain-containing protein 1A

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANKS1A Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (8 - 107)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (117 - 208)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (215 - 277)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (699 - 759)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (769 - 830)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (942 - 1068)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1134 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and SAM domain-containing protein 1A

  • Odin

ANKS1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
ANKS1A Q92625 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
ANKS1A Q92625 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Intra
ANKS1A Q92625 EGFR Homo sapiens P00533
Anti Tag CoIP
24658140
Intra
ANKS1A Q92625 ERBB2 Homo sapiens P04626
Protein Array
16273093
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autotopagnosia

  • Body-Image Agnosia
Benign Secondary Hypertension
Benign Renovascular Hypertension
Dressler'S Syndrome

  • Dressler Syndrome

  • Postmyocardial Infarction Syndrome

  • Donath-Landsteiner Hemolytic Anemia

  • Post-Myocardial Infarction Syndrome

  • Postmyocardial Infarction Pericarditis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00735 ANKS1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANKS1A MGD MGI:2446180
Macaca mulatta ANKS1A VGNC VGNC:69657
Rattus norvegicus ANKS1A RGD RGD:1309183
Canis familiaris ANKS1A VGNC VGNC:37916
Felis catus ANKS1A VGNC VGNC:59820
Bos taurus ANKS1A VGNC VGNC:25944
Others ANKS1A NCBI