PSCA - prostate stem cell antigen Gene

Also Known as PRO232; lncPSCA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8000

About PSCA

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,670,297-142,682,725 (from NCBI)

This gene has 4 transcripts (splice variants), 93 orthologues and 2 paralogues. Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue.

Summary

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

PSCA Products (1)

mRNA	Protein	Name
NM_005672.5	NP_005663.2	prostate stem cell antigen preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables acetylcholine receptor binding	IDA IDA: Inferred from direct assay	25680266	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	25680266	GOA
involved in regulation of neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	25680266	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSCA Protein Structure

UPAR_LY6

0
100
114 a.a.

Protein Preferred Names	Protein Names
prostate stem cell antigen

Recombinant PSCA Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P78013	PSCA Protein, Human (HEK293, Fc)	O43653 (L12-S86)	≥ 95%, as determined by Bis-Tris PAGE.

PSCA Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81734	PSCA Antibody (YA1479)	IHC-P, FC, ELISA	Human
HY-P83846	PSCA Antibody (YA3543)	ICC/IF, FC, ELISA	Human
HY-P83846A	PSCA Antibody (YA3543)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P85819	PSCA Antibody (YA5511)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cardia Cancer	Ca Cardia - Stomach Malignant Neoplasm Of Cardia Of Stomach
Colloid Carcinoma Of The Pancreas
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS11271	PSCA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168943C	PLGA nanoparticles, 1μm		/	Unkown
HY-RS17893	Psca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24362	Psca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P990319	ALT-100 (Human IgG4)	Inhibitor	≥99.0%	Unkown
HY-P991075	ALT-100 (Human IgG1)	Inhibitor	99.90%	Unkown
HY-P991229	MK-4721		96.66%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSCA	MGD	MGI:1919623
Rattus norvegicus	PSCA	RGD	RGD:1594221
Macaca mulatta	PSCA	VGNC	VGNC:99472
Canis familiaris	PSCA	VGNC	VGNC:56075
Others	PSCA	NCBI