Griselimycin
Based on 1 Customer Validation
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.2%
- No. CAS: 26034-16-2
- Fòrmula: C57H96N10O12
- Peso molecular:1113.43
-
Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Griselimycin (0-200 μM) binds to β-clamp homologs from various Gram-negative and Gram-positive bacteria with high selectivity and variable affinities ranging from submicromolar to nanomolar, among which the interaction with Bartonella birtlesii β-clamp is the strongest (Kd = 6.9 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 26034-16-2
-
Appearance Solid
-
Peso molecular 1113.43
-
Fòrmula C57H96N10O12
-
Color White to off-white
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
-
Ficha de datos (258 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Holzgrabe U, et al. New Griselimycins for Treatment of Tuberculosis. Chem Biol. 2015;22(8):981-982. [Content Brief]
[2]. Fenwick MK, et al. Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens. Commun Biol. 2024;7(1):1622. Published 2024 Dec 5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Griselimycin Related Classifications
HY-125576 Related Classifications
Powered by Bioz