HX009
Based on 1 Customer Validation
HX009 is a bispecific antibody targeting PD1 and CD47, but with weakened CD47 binding. HX009 blocks the functional of PD1/CD47. HX009 can be used for the study of non-Hodgkin’s lymphoma (NHL).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.56%
- Peso molecular:173.16 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD47 & PD-1
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Q61735-1 & Q02242
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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extracellular CD47-binding domain of human SIRPα protein at the C-terminus (Fc) of the heavy chain of HX008
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized human PD-1-His can bind HX009. The EC50 for this effect is 55.64 ng/mL. -
Immobilized human-CD47-His can bind HX009. The EC50 for this effect is 172.1 ng/mL.
Chemical Information
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Appearance Liquid
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Peso molecular 173.16 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)