Hydroxy Bosentan-d6
Hydroxy Bosentan-d6 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.
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- No. CAS: 1246817-57-1
- Fòrmula: C27H23D6N5O7S
- Peso molecular:573.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1246817-57-1
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Unlabeled Cas 253688-60-7
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Peso molecular 573.65
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Fòrmula C27H23D6N5O7S
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SMILES
O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=C(C=CC=C3)OC)(C4=CC=C(C=C4)C(C([2H])([2H])[2H])(C([2H])([2H])[2H])CO)=O
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Synonyms
Ro 48-5033-d6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydroxy Bosentan-d6 Related Classifications
HY-121385S Related Classifications
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