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Referencia número: HY-P99659

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Biologically Validated

Imsidolimab

Name: Imsidolimab
Brand: MedChemExpress
SKU: HY-P99659
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ANB 019)

Revisión del cliente

Based on 1 Customer Validation

Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.63%
No. CAS: 2102543-86-0
Peso molecular:146.6 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Imsidolimab Chemical Structure

No. CAS: 2102543-86-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-1RL2/IL-36R

Ver todos los productos específicos de isoformas Interleukin Related :

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

8808 [NCBI]

Accession

Q9HB29

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-1RL2 Protein, Human can bind Imsidolimab. The EC₅₀ for this effect is 13.23 ng/mL.

Chemical Information

No. CAS 2102543-86-0
Appearance Liquid
Peso molecular 146.6 kDa
Color Colorless to light yellow
SMILES

[Imsidolimab]
Synonyms

ANB 019
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Gudjonsson J E, et al. 34617 Imsidolimab in the treatment of adult subjects with generalized pustular psoriasis: Design of a pivotal phase 3 clinical trial and a long-term extension study[J]. Journal of the American Academy of Dermatology, 2022, 87(3): AB70.

[2]. Iznardo H, et al. Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease. Int J Mol Sci. 2021 Apr 21;22(9):4344. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Biological Activity
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Imsidolimab

Bradford Protein Assay Kit

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Ver todos los productos específicos de isoformas Interleukin Related