Keratinase
Keratinase (KerA) is an orally active proteolytic enzyme that specifically degrades keratin, and it is mainly secreted by microorganisms such as bacteria, fungi and actinomycetes. Keratinase degrades keratin via reducing disulfide bond cross-links and cleaving peptide bonds, and it can also degrade infectious prion proteins. Keratinase can improve the nutritional bioavailability of keratin-based feed, and it can also be applied in various fields including depilation, proteolytic cleaning, organic fertilizer precursor preparation, cosmetics, bioenergy production, wastewater decolorization, biomolecule extraction, bioremediation, textile biopretreatment and feed processing.
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- No. CAS: 37341-53-0
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
Keratinase is derived from various bacterial and fungal sources, and exhibits stable activity in keratin degradation, prion inactivation, and leather unhairing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Versazyme keratinase (p.o.; continuous feeding) improves growth performance, feed efficiency, and intestinal function in broiler chickens[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Weaned piglets[2]
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Dosage:0.05% (w/w)
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Administration:p.o.; continuous feeding
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Result:Increased glycine hydrolysis from 11.81% to 94.74%.
Increased β-conglycinin hydrolysis from 24.20% to 88.89%.
Reduced intestinal E. coli count, total aerobic counts, ammonia nitrogen concentration, and branched-chain volatile fatty acid content.
Improved intestinal architecture and ecology.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 37341-53-0
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Appearance Solid
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Color White to off-white
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SMILES
[Keratinase]
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Synonyms
KerA
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Protocol for Pharmacokinetic Study
Pharmacokinetic studies quantify how an organism handles a drug over time through absorption, distribution, metabolism, and excretion, and the core experimental readout is the concentration-time profile of parent drug and, when relevant, metabolites in biological matrices such as plasma, whole blood, urine, bile, or tissue. Pharmacokinetic analysis links dose, route, exposure, clearance, half-life, distribution, bioavailability, and systemic exposure to drug efficacy and toxicity hypotheses rather than measuring a signaling pathway directly. The literature links pharmacokinetics to drug-development phenotypes by showing that drug metabolism and pharmacokinetics influence compound progression, exposure-response interpretation, safety margins, dosing strategy, and failure risk during discovery and development. DMPK science contributes to compound optimization by integrating physicochemical properties, in vitro metabolism, transporter behavior, in vivo exposure, and pharmacodynamic contex
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keratinase Related Classifications
HY-E70193 Related Classifications
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