Copy Link Print Information

KY-1044

(Synonyms: Alomfilimab; SAR 445256)
Revisión del cliente

Based on 1 Customer Validation

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.51%
  • No. CAS: 2489390-15-8
  • Peso molecular:146.5 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • KY-1044 Chemical Structure
    KY-1044 Chemical Structure
No. CAS: 2489390-15-8
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
KY-1044 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products
Keywords
MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.

  • 1/16

    Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).

  • KY-1044 Chemical Structure
    1/16
  • KY-1044
  • Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.
  • Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).