Mitomycin A
Based on 1 Customer Validation
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.
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- Pureza: 98.3%
- No. CAS: 4055-39-4
- Fòrmula: C16H19N3O6
- Peso molecular:349.34
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.006 μg/mL
Compound: 16
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in vitro anticancer activity against cultured A549 human tumor(lung) cell line
in vitro anticancer activity against cultured A549 human tumor(lung) cell line
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[PMID: 11585450] |
| CCRF S-180 | ED50 |
1.1 μg/mL
Compound: 28
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Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
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[PMID: 19540628] |
| CCRF S-180 | ED50 |
1.3 mg/kg
Compound: mitomycin A
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Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice
Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice
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[PMID: 8021919] |
| HCT-8 | IC50 |
0.006 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line
in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line
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[PMID: 11585450] |
| HeLa | IC50 |
0.0024 μM
Compound: mitomycin A
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In vitro anticellular activity tested against HeLa S3 cells
In vitro anticellular activity tested against HeLa S3 cells
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[PMID: 8021918] |
| HeLa | IC50 |
0.0024 μM
Compound: mitomycin A
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In vitro anticellular activity against HeLa S3 cells
In vitro anticellular activity against HeLa S3 cells
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[PMID: 8021919] |
| HepG2 | IC50 |
0.008 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line
in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line
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[PMID: 11585450] |
| KB | IC50 |
0.008 μg/mL
Compound: 16
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in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line
in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line
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[PMID: 11585450] |
| L1210 | IC50 |
0.0023 μM
Compound: 6
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Inhibitory concentration on multidrug-resistant L1210 leukemia cells.
Inhibitory concentration on multidrug-resistant L1210 leukemia cells.
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[PMID: 1906107] |
| L1210 | IC50 |
0.0003 μM
Compound: 6
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Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
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[PMID: 1906107] |
| L1210 | IC50 |
0.3 nM
Compound: 6
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Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
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[PMID: 1906107] |
| MCF7 | IC50 |
0.045 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line
in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line
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[PMID: 11585450] |
| MCF7 | IC50 |
0.63 nM
Compound: 20
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Antitumor potency on human breast MCF-7 cell lines.
Antitumor potency on human breast MCF-7 cell lines.
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[PMID: 1906109] |
| P388 | IC50 |
0.24 nM
Compound: 20
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Antitumor potency on P388 leukemia cells in culture
Antitumor potency on P388 leukemia cells in culture
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[PMID: 1906109] |
| PC-3 | IC50 |
0.02 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line
in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line
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[PMID: 11585450] |
| U-87MG ATCC | IC50 |
0.009 μg/mL
Compound: 16
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in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line
in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line
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[PMID: 11585450] |
| WiDr | IC50 |
0.052 nM
Compound: 20
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Antitumor potency on human colon WIDR cell lines.
Antitumor potency on human colon WIDR cell lines.
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[PMID: 1906109] |
Mitomycin A (0.05-5 μg/mL; 24 h) inhibits the spontaneous migration of WEHI-3 mouse monocytes in a concentration-dependent manner[1].
Mitomycin A (0.25 μg/mL; 65 h) significantly inhibits the production of migration inhibitory factor (MIF) by pokeweed mitogen-activated human lymphocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WEHI-3 murine myelomonocytic leukemia cells
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Concentration:0.05 μg/mL; 0.1 μg/mL; 0.5 μg/mL; 5 μg/mL
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Incubation Time:24 h
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Result:Exhibited a migration index (MI) of 1.01 ± 0.05 at 0.05 μg/mL.
Showed a migration index (MI) of 1.03 ± 0.03 at 0.1 μg/mL.
Reduced the mean migration index (MI) to 0.65 ± 0.01 at 0.5 μg/mL, with a statistically significant decrease.
Lowered the mean migration index (MI) to 0.52 ± 0.02 at 5 μg/mL, with a statistically significant decrease.
Caused no statistically significant decreases in migration at 0.05 and 0.1 μg/mL.
Chemical Information
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No. CAS 4055-39-4
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Appearance Solid
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Peso molecular 349.34
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Fòrmula C16H19N3O6
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Color Purple to purplish red
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SMILES
O=C1C(C)=C(OC)C(C2=C1N3[C@@]([C@](N4)([H])[C@]4([H])C3)(OC)[C@@H]2COC(N)=O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mitomycin A Related Classifications
HY-130332 Related Classifications
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