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Referencia número: HY-111282

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MK-789

MK-789 is a competitive reversible inhibitor of dehydropeptidase I (DHP-I). MK-789 competitively blocks the entry of N-formimidoylthienamycin into proximal tubular cells, thereby inhibiting its renal metabolism. MK-789 shifts the renal excretion pathway of N-formimidoylthienamycin to glomerular filtration only, increasing its urinary recovery rate and renal clearance. MK-789 is applicable to studies on renal metabolism and pharmacokinetics.

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No. CAS: 85394-14-5
Fòrmula: C₁₄H₂₃NO₃
Peso molecular:253.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-789 Chemical Structure

No. CAS: 85394-14-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Dipeptidyl Peptidase :

In Vitro

MK-789 and its oxidative metabolites inhibit purified dehydropeptidase I in spectrophotometric assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-789 (25, 75, 150 mg; intravenous injection; single administration; 7-day washout period between each dose) increases the urinary recovery rate of co-administered 150 mg N-formimidoylthienamycin to a plateau value of approximately 61% in healthy Caucasian male subjects; it elevates the plasma AUC of co-administered N-formimidoylthienamycin by approximately 20% without altering its plasma half-life^[1].\n

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 85394-14-5
Peso molecular 253.34
Fòrmula C₁₄H₂₃NO₃
SMILES

O=C(/C(NC(C1CC1(C)C)=O)=C\CCCCC)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Norrby SR, et al. Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors. Antimicrobial agents and chemotherapy. 1983 Feb;23(2):300-7. [Content Brief]

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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