MRK-A
MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors.
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- No. CAS: 1934301-68-4
- Fòrmula: C28H30N4O2
- Peso molecular:454.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
IC50: 5 nM (mutant IDH1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOG-G-UVW | IC50 |
43 nM
Compound: MRK-A
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Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
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[PMID: 35450359] |
Chemical Information
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No. CAS 1934301-68-4
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Peso molecular 454.56
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Fòrmula C28H30N4O2
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SMILES
O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRK-A Related Classifications
HY-124698 Related Classifications
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