MRL-494
Based on 1 publication(s) in Google Scholar
MRL-494, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias.
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- No. CAS: 2434898-43-6
- Fòrmula: C26H35FN16O2
- Peso molecular:622.66
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Actividad biológica
β-barrel assembly machine A (BamA)[1]
MRL-494 lethally disrupts the cytoplasmic membrane. MRL-494 inhibits OM proteins (OMPs) biogenesis from outside the outer membrane (OM) by targeting BamA. MRL-494 exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of MRL-494 against E. coli (WT), E. coli (ΔtolC), E. coli (ΔtolC envA101), K. pneumonia, A. baumannii (WT), A. baumannii (ΔlpxC) , P. aeruginosa (efflux deficient), P. aeruginosa (WT), Staphylococcus aureus (methicillin-resistant) and Bacillus subtilis rpoB18 are 25 μM, 25 μM, 25 μM, 100 μM, 200 μM, 200 μM, 100 μM, 100 μM, 12.5 μM and 25 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2434898-43-6
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Peso molecular 622.66
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Fòrmula C26H35FN16O2
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SMILES
FC1=CC=C(C2=NN(CC(N[C@@H]3CC[C@H](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326. [Abstract]2025 Jan;301(1):108018. PMID: 39608713
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRL-494 Related Classifications
HY-128773 Related Classifications
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