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Referencia número: HY-137156

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NB-64

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 53242-68-5
Fòrmula: C₁₁H₈ClNO₂
Peso molecular:221.64

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NB-64 Chemical Structure

No. CAS: 53242-68-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections^[1].

IC₅₀ & Target

HIV-1

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human MT2 cells Toxicity against human MT2 cells	[PMID: 26116177]
MT2	CC₅₀	335.7 μM Compound: 1, NB-64	Cytotoxicity against human MT2 cells after 4 days using XTT assay Cytotoxicity against human MT2 cells after 4 days using XTT assay	[PMID: 22014749]
MT2	CC₅₀	335.72 μM Compound: A1, NB-64	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	EC₅₀	2.39 μM Compound: A1, NB-64	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]
MT2	EC₅₀	2.4 μM Compound: 1, NB-64	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA	[PMID: 22014749]
MT2	EC₅₀	29.92 μM Compound: 15ii, NB-64	Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells	[PMID: 26116177]
U373-MAGI	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human U373-MAGI-CXCR4-CEM cells Toxicity against human U373-MAGI-CXCR4-CEM cells	[PMID: 26116177]
U-87MG ATCC	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human U87-T4-CXCR4 cells Toxicity against human U87-T4-CXCR4 cells	[PMID: 26116177]

Chemical Information

No. CAS 53242-68-5
Peso molecular 221.64
Fòrmula C₁₁H₈ClNO₂
SMILES

O=C(C1=CC(N2C=CC=C2)=CC=C1Cl)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jiang S, et al. N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion. Antimicrob Agents Chemother. 2004 Nov;48(11):4349-59. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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NB-64

Ver todos los productos específicos de isoformas HIV

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

NB-64 Related Classifications

HY-137156 Related Classifications