NP-184
NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 78706-11-3
- Fòrmula: C12H10N2O
- Peso molecular:198.22
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 4.3 μM (TXA2 synthase)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HepG2 | IC50 |
102.54 μM
Compound: 4b
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 28505536] |
| MCF7 | IC50 |
14 μg/mL
Compound: 3b
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Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
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[PMID: 24576797] |
| MCF7 | IC50 |
55.55 μM
Compound: 4b
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 28505536] |
Chemical Information
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No. CAS 78706-11-3
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Appearance Solid
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Peso molecular 198.22
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Fòrmula C12H10N2O
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Color Light brown to brown
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3N2)O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NP-184 Related Classifications
HY-W169940 Related Classifications
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