NS 1231
NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke.
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- No. CAS: 309711-72-6
- Fòrmula: C18H15ClN2O2
- Peso molecular:326.78
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
NS 1231 (1-10 μM) increases the viability of NGF-differentiated PC12 cells and preserves the neurites of surviving cells when administered for 4 days after trophic factor (serum and NGF) withdrawal[1].
NS 1231 (1-3 μM, 48 h) in combination with NGF significantly stimulates neurite outgrowth in undifferentiated PC12 cells[1].
NS 1231 (1-3 μM, 5 mins) in combination with NGF enhances NGF-induced TrkA phosphorylation at the Shc-binding site (Tyr490) and ERK activation (Thr202/Tyr204) in undifferentiated PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with middle cerebral artery occlusion (MCAO)[1]
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Dosage:15 mg/kg
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Administration:Intraperitoneally injection, 2 mins after MCAO
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Result:Reduced the total infarct volume by 43% after 4 days.
Chemical Information
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No. CAS 309711-72-6
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Peso molecular 326.78
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Fòrmula C18H15ClN2O2
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SMILES
O=C1NC2=C(C=C(C3=CC=C(Cl)C=C3)C4=C2CCCC4)/C1=N/O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NS 1231 Related Classifications
HY-165616 Related Classifications
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