PRO-HD3
PRO-HD3 is a HDAC6 PROTAC degrader. PRO-HD3 exerts antiproliferative activity in leukemia cells. PRO-HD3 can be used for leukemia research.
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W015659)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3126555-94-7
- Fòrmula: C40H43N5O5S
- Peso molecular:705.86
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W015659)).
PRO-HD3 (500 nM-5 μM; 24 h) nearly completely degrades HDAC6 in A549 cells at a concentration of 5 μM after 24 h of incubation[1].
PRO-HD3 (48 h) inhibits Jurkat cell proliferation with an IC50 of 3.80 μM after 48 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:adenocarcinomic human alveolar basal epithelial A549 cells
-
Concentration:500 nM, 1 μM, 5 μM
-
Incubation Time:24 h
-
Result:Nearly completely depleted HDAC6 protein at 5 μM.
Partially degraded HDAC6 protein at lower concentrations.
Chemical Information
-
No. CAS 3126555-94-7
-
Peso molecular 705.86
-
Fòrmula C40H43N5O5S
-
SMILES
S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRO-HD3 Related Classifications
HY-155398 Related Classifications
Powered by Bioz