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Referencia número: HY-B0279S1

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Ramipril-d₃

Name: Ramipril-d3
Brand: MedChemExpress
SKU: HY-B0279S1
Price: 770.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: HOE-498-d₃)

Ramipril-d₃ (HOE-498-d₃) is the deuterated-labeled Ramipril (HY-B0279). Ramipril (HOE-498) is an orally active angiotensin-converting enzyme (ACE) inhibitor with blood-brain barrier permeability, and it is metabolized in vivo to the active metabolite Ramiprilat (HY-A0115). Ramipril has antioxidant, vasoprotective, and anti-atherosclerotic effects. Ramipril reduces the degradation of angiotensin II and bradykinin, downregulates TGF-beta/CTGF/fibronectin/α-SMA, and inhibits pancreatic/cardiac fibrosis. Ramipril improves glucose tolerance and insulin secretion, and reduces weight gain/appetite. Ramipril sensitizes mast cells, enhances FcεRI histamine release/degranulation, aggravates IgE allergic reactions, and downregulates the bradykinin receptor. Ramipril improves vascular endothelial relaxation function in spontaneously hypertensive rats. Ramipril alleviates Oxaliplatin (HY-17371)-induced acute hyperalgesia in mice. Ramipril can be used in research related to diseases such as type 2 diabetes, rheumatoid arthritis, allergy, and hypertension.

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No. CAS: 2673269-81-1
Fòrmula: C₂₃H₂₉D₃N₂O₅
Peso molecular:419.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (291 KB)

Ramipril-d₃ Chemical Structure

No. CAS: 2673269-81-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target

^[3]^[1]

Bradykinin B1 Receptor (B1R)

ACE

Ver todos los productos específicos de isoformas Bradykinin Receptor :

Ver todos los productos específicos de isoformas TGF-beta/Smad :

Smad1
Smad3

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 2673269-81-1
Unlabeled CAS 87333-19-5
Peso molecular 419.53
Fòrmula C₂₃H₂₉D₃N₂O₅
SMILES

CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C([2H])([2H])[2H])C(N2[C@]3([H])[C@](CCC3)([H])C[C@H]2C(O)=O)=O)=O
Synonyms

HOE-498-d₃
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (291 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Ko SH, et al. Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochemical and biophysical research communications. 2004 Mar 26;316(1):114-22.

[2]. Shi Q, et al. Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis. Arthritis research & therapy. 2012 Oct 18;14(5):R223.

[3]. Nassiri M, et al. Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming. The Journal of allergy and clinical immunology. 2015 Feb;135(2):491-9.

[4]. Hutri-Kähönen N, et al. Ramipril therapy improves arterial dilation in experimental hypertension. Cardiovascular research. 1997 Jan;33(1):188-95.

[5]. Bouchenaki H, et al. Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice. Frontiers in pharmacology. 2021;12:712442.

[6]. Jenrow KA, et al. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat Oncol. 2010 Feb 1;5:6.

Calculators

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ramipril-d₃

Ver todos los productos específicos de isoformas Bradykinin Receptor

Ver todos los productos específicos de isoformas TGF-beta/Smad