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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
96 Results for "
urinary bladder
" in MedChemExpress (MCE) Product Catalog:
Products (96)
96 Results for "urinary bladder" in MCE Product Catalog:
Referencia número: HY-182599
No. CAS: 129927-37-3
Target:
Áreas de investigación:
RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K + currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity .
Referencia número: HY-90010S
No. CAS: 1191280-48-4
Synonyms: Kabi-2234-d14; PNU-200583E-d14
Referencia número: HY-177995
No. CAS: 142609-62-9
Synonyms: Monoisoamyl meso-2,3-dimercaptosuccinic acid
Target:
Áreas de investigación:
MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals. Arsenic binds with two vicinal sulfhydryl groups available in MiADMSA leading to marked reduction in body arsenic burden and also marked reduction in various oxidative stress parameters and antioxidant enzymes like-ROS, nitrite, TBARS, GSH, SOD and catalase. MiADMSA attenuates urinary bladder carcinogenesis, protects against oxidative stress, ameliorates copper-induced histopathology, reverses neurotoxicity, and is safe in animals. MiADMSA can be used in studies of bladder cancer, arsenic, and lead-induced developmental neurotoxicity .
Referencia número: HY-184039
No. CAS: 88124-26-9
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Áreas de investigación:
Adosupine is a tricyclic compound that affects detrusor hyperreflexia via central nervous system sites. Adosupine can be used in studies related to detrusor hyperreflexia and urinary incontinence .
Referencia número: HY-W409652
No. CAS: 2101206-26-0
CLK1/4-IN-2 is a selective CLK1/4 inhibitor, with an IC50 of 7 nM against CLK1 and an IC50 of 2.3 nM against CLK4. CLK1/4-IN-2 induces protein depletion in cancer cells and exhibits anticancer activity. CLK1/4-IN-2 can be used in research related to breast cancer, monocytic leukemia, bladder cancer, mammary adenocarcinoma and hepatocellular carcinoma .
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Emepronium bromide is an antispasmodic agent for the bladder and a muscarinic receptor ligand, with an IC50 of 236 nM. Emepronium bromide is applicable to research related to bladder diseases .
Referencia número: HY-P1278B
Target:
Áreas de investigación:
Referencia número: HY-B0985AS
No. CAS: 1287380-98-6
Target:
Áreas de investigación:
Phenazopyridine-d5 is the deuterated-labeled Phenazopyridine (HY-B0985A). Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .
Referencia número: HY-P2593
No. CAS: 125989-15-3
Target:
Áreas de investigación:
Referencia número: HY-N11811
No. CAS: 117405-52-4
Referencia número: HY-119753
No. CAS: 68284-69-5
Synonyms: SC-31828
Target:
Áreas de investigación:
Disobutamide (SC-31828) is an orally active, blood-brain barrier permeable cationic amphiphilic ditertiary amine piperidine ring compound with antiarrhythmic properties. Disobutamide induces lysosomal phospholipid accumulation, which triggers extensive cytoplasmic vacuolization and leads to cell death. Disobutamide prolongs multiple electrocardiographic intervals in canine hearts, induces cardiac arrest at high doses, and causes decreased retinal reflectivity. Disobutamide can be used in studies related to arrhythmias, and also serves as a model drug for investigating the storage mechanisms and toxicity thresholds of intracellular amphiphilic compounds .
Referencia número: HY-181567
No. CAS: 3079150-70-9
METTL3-IN-13 is a METTL3 inhibitor. METTL3-IN-13 is applicable to the research of multiple cancers such as hypopharyngeal squamous cell carcinoma and non-small cell lung cancer .
Referencia número: HY-183206
No. CAS: 149455-36-7
Target:
Áreas de investigación:
UR 8225 is an orally active ATP-sensitive K + channel activator with vasodilator, smooth muscle relaxant, antihypertensive, and bronchodilator activities. UR 8225 induces membrane hyperpolarization by increasing outward K + conductance and reduces Ca 2+ influx through voltage-gated L-type Ca 2+ channels. UR 8225 reduces total peripheral vascular resistance, shortens cardiac action potential duration, inhibits agonist-induced Ca 2+ influx, and stimulates renin release. UR 8225 induces reflex tachycardia but lacks β-adrenergic receptor blocking activity. UR 8225 is widely applicable to research in fields related to hypertension, myocardial ischemia, ventricular fibrillation, and other conditions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
