L-659874
L-659874 is a selective NK2 receptor antagonist with an IC50 value of 0.49 μM in hamsters. L-659874 inhibits NK2 receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses.
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- No. CAS: 125989-15-3
- Fòrmula: C40H55N9O8S
- Peso molecular:822.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Hamster Bladder NK-2 0.49 μM (IC50) |
In Vitro
L-659874 (preincubated for 15 min prior to stimulation with Eledoisin (HY-P0006); co-incubated with Eledoisin for a total duration of 45 min at 0.01-100 μM) potently inhibits NK2 receptor-mediated Eledoisin-induced phosphatidylinositol hydrolysis in hamster bladder slices, with an IC50 of 0.49 μM[1].
L-659874 blocks the binding of iodine-125-labeled BH-Eledoisin to hamster bladder cell membranes, with an IC50 of 0.04 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 125989-15-3
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Peso molecular 822.00
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Fòrmula C40H55N9O8S
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SMILES
C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
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Sequence
Ac-Leu-Met-Gln-Trp-Phe-Gly-NH2
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Sequence Shortening
Ac-LMQWFG-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-659874 Related Classifications
HY-P2593 Related Classifications
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