L-659874
L-659874 is a selective NK2 receptor antagonist with an IC50 value of 0.49 μM in hamsters. L-659874 inhibits NK2 receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses.
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- No. CAS: 125989-15-3
- Fòrmula: C40H55N9O8S
- Peso molecular:822.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Hamster Bladder NK-2 0.49 μM (IC50) |
In Vitro
L-659874 (preincubated for 15 min prior to stimulation with Eledoisin (HY-P0006); co-incubated with Eledoisin for a total duration of 45 min at 0.01-100 μM) potently inhibits NK2 receptor-mediated Eledoisin-induced phosphatidylinositol hydrolysis in hamster bladder slices, with an IC50 of 0.49 μM[1].
L-659874 blocks the binding of iodine-125-labeled BH-Eledoisin to hamster bladder cell membranes, with an IC50 of 0.04 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 125989-15-3
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Peso molecular 822.00
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Fòrmula C40H55N9O8S
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SMILES
C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
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Sequence
Ac-Leu-Met-Gln-Trp-Phe-Gly-NH2
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Sequence Shortening
Ac-LMQWFG-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-659874 Related Classifications
HY-P2593 Related Classifications
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