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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
complement factor B
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "complement factor B" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: LNP023
Target:
Áreas de investigación:
Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
14
14 Publications Verification
Synonyms: LNP023 hydrochloride
Target:
Áreas de investigación:
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
2
2 Cited Publications
Referencia número: HY-P70485
Pureza: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: VTN; Vitronectin; VN; Serum Spreading factor; Serum-Spreading factor; complement S-Protein; Somatomedin B; S-Protein; V75; Vitronectin (Serum Spreading factor, Somatomedin B, complement S-Protein); Epibolin; VNT
Species:
Human
Source:
HEK293
1
1 Cited Publications
Referencia número: HY-P73484
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VTN; Vitronectin; VN; Serum Spreading factor; Serum-Spreading factor; complement S-Protein; Somatomedin B; S-Protein; V75; Vitronectin (Serum Spreading factor, Somatomedin B, complement S-Protein); Epibolin; VNT
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Referencia número: HY-P72137
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CFB; complement factor B Preproprotein; Prev. BFD; Glycine-Rich Beta Glycoprotein; Prev. BF; C3 Proaccelerator; Properdin factor B; C3 Proactivator; C3/C5 Convertase; ARMD14; H2-Bf; AHUS4; B-factor, Properdin; FBI12; Properdin B; CFAB; PBF2; CFBD; GBG; FB
Species:
Mouse
Source:
E. coli
Synonyms: ARC1905
Target:
Áreas de investigación:
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
Referencia número: HY-NP004
Synonyms: CVF
Target:
Áreas de investigación:
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .
Synonyms: IONIS-FB-LRx sodium; RG6299 sodium; ISIS 696844 sodium
Target:
Áreas de investigación:
Sefaxersen sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .
Referencia número: HY-148370
No. CAS: 2272975-74-1
Synonyms: IONIS-FB-LRx; RG6299; ISIS 696844
Target:
Áreas de investigación:
Sefaxersen (IONIS-FB-LRx) is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen effectively reduces circulating levels of CFB. Sefaxersen can be used for geographic atrophy (GA) research .
Referencia número: HY-P99298
No. CAS: 1278466-20-8
Synonyms: RG 7417; TNX 234; Anti-CFD Recombinant Antibody
Target:
Áreas de investigación:
Referencia número: HY-177611
No. CAS: 2985646-78-2
Target:
Áreas de investigación:
Agazisiran, a siRNA,is a complement factor B synthesis reducer.
Referencia número: HY-200854
No. CAS: 2447007-60-3
Synonyms: LNP023 hydrochloride hydrate
Target:
Áreas de investigación:
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
Referencia número: HY-P2830
No. CAS: 37213-56-2
Target:
Áreas de investigación:
Complement factor D is a serine protease. Complement factor D activates C3 convertase by specifically cleaving complement Factor B. Complement factor D is promising for research of autoimmune diseases (e.g., paroxysmal nocturnal hemoglobinuria, C3 glomerulopathy), age-related macular degeneration, and thrombotic microangiopathies .
Referencia número: HY-178284
Target:
Áreas de investigación:
Factor B-IN-7 (Compound (I)) is a selective Factor B inhibitor. Factor B-IN-7 inhibits Factor B-C3b interaction to suppress complement hyperactivation. Factor B-IN-7 is promising for research of paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy, and age-related macular degeneration (AMD) associated with complement-mediated diseases .
Referencia número: HY-174913
No. CAS: 1644670-23-4
Target:
Áreas de investigación:
Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy .
Referencia número: HY-177611A
Target:
Áreas de investigación:
Agazisiran sodium, a siRNA,is a complement factor B synthesis reducer.
Referencia número: HY-147605
No. CAS: 2760669-74-5
Target:
Áreas de investigación:
Factor B-IN-3 (Example 3 target compound) is a potent complement factor B inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .
Referencia número: HY-147606
No. CAS: 2760669-84-7
Target:
Áreas de investigación:
Factor B-IN-4 (Example 13 target compound) is a potent complement factor B inhibitor, with an IC50 of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .
Referencia número: HY-147607
No. CAS: 2797066-85-2
Target:
Áreas de investigación:
Factor B-IN-5 (Example 5 target compound) is a potent complement factor B inhibitor, with an IC50 of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
