SU0617
Based on 1 Customer Validation
SU0617 is a selective SMUG1 inhibitor with a human IC50 of 1.5 μM. SU0617 inhibits base excision repair activity of SMUG1, including excision of modified and damaged pyrimidines from DNA. SU0617 can be used for the research of breast cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.56%
- Fòrmula: C21H15ClN4OS
- Peso molecular:406.89
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
SU0617 (1-10 μM; 10-25 min) potently inhibits recombinant human SMUG1 with an IC50 of 1.5 μM[1].
SU0617 (1-10 μM) shows selective inhibition of recombinant human SMUG1 over bacterial UDG[1].
SU0617 (5 μM; 3 h) causes near-complete inhibition of recombinant human SMUG1-mediated DNA base excision[1].
SU0617 (48 h) exhibits minimal cytotoxicity in Hs578T and BT549 human breast cancer cell lines after 48 h of incubation, with an IC50 above 10 μM in both lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Peso molecular 406.89
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Fòrmula C21H15ClN4OS
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Color Off-white to light yellow
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SMILES
ClC1=CC=C(C2=CSC(NC3=CC=C(NC(C4=CC=CN=C4)=O)C=C3)=N2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (122.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4577 mL | 12.2883 mL | 24.5767 mL | 61.4417 mL |
| 5 mM | 0.4915 mL | 2.4577 mL | 4.9153 mL | 12.2883 mL | |
| 10 mM | 0.2458 mL | 1.2288 mL | 2.4577 mL | 6.1442 mL | |
| 15 mM | 0.1638 mL | 0.8192 mL | 1.6384 mL | 4.0961 mL | |
| 20 mM | 0.1229 mL | 0.6144 mL | 1.2288 mL | 3.0721 mL | |
| 25 mM | 0.0983 mL | 0.4915 mL | 0.9831 mL | 2.4577 mL | |
| 30 mM | 0.0819 mL | 0.4096 mL | 0.8192 mL | 2.0481 mL | |
| 40 mM | 0.0614 mL | 0.3072 mL | 0.6144 mL | 1.5360 mL | |
| 50 mM | 0.0492 mL | 0.2458 mL | 0.4915 mL | 1.2288 mL | |
| 60 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0240 mL | |
| 80 mM | 0.0307 mL | 0.1536 mL | 0.3072 mL | 0.7680 mL | |
| 100 mM | 0.0246 mL | 0.1229 mL | 0.2458 mL | 0.6144 mL |
SU0617 Related Classifications
HY-184013 Related Classifications
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