T-1095
Based on 1 Customer Validation
T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.40%
- No. CAS: 209746-59-8
- Fòrmula: C26H28O11
- Peso molecular:516.49
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Anti-diabetic Compound Library
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Anti-Obesity Compound Library
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Actividad biológica
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hSGLT1 22.8 μM (IC50) |
hSGLT2 2.3 μM (IC50) |
Orally administered T-1095 (3-30 mg/kg) increases urinary glucose excretion in diabetic animals, thereby decreasing blood glucose levels[1].
With long-term T-1095 (0.01% or 0.1% T-1095 mixed diet; for 28 days) treatment, both blood glucose and HbA1c levels were reduced in streptozotocin (STZ)-induced diabetic rats and yellow KK mice. In addition, there was amelioration of abnormal carbohydrate metabolism, i.e., hyperinsulinemia and hypertriglyceridemia, and of the development of microalbuminuria, in yellow KK mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 209746-59-8
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Appearance Solid
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Peso molecular 516.49
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Fòrmula C26H28O11
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Color Off-white to light yellow
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SMILES
O=C(C(C(O)=C1)=C(C=C1C)O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)COC(OC)=O)CCC3=CC=C4C(C=CO4)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (48.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9361 mL | 9.6807 mL | 19.3615 mL | 48.4036 mL |
| 5 mM | 0.3872 mL | 1.9361 mL | 3.8723 mL | 9.6807 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9361 mL | 4.8404 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2908 mL | 3.2269 mL | |
| 20 mM | 0.0968 mL | 0.4840 mL | 0.9681 mL | 2.4202 mL | |
| 25 mM | 0.0774 mL | 0.3872 mL | 0.7745 mL | 1.9361 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6135 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2101 mL |
T-1095 Related Classifications
HY-106158 Related Classifications
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