YPC-22026
YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities.
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- No. CAS: 1964457-41-7
- Fòrmula: C16H8F3N3O2
- Peso molecular:331.25
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
YPC‐22026 (96 h) shows cytotoxic to HCT116 and PC‐3 with IC50 values of 0.33 μM and 0.66 μM, respectively[1].
YPC‐22026 (3 μM; 24 h) induces G2/M arrest and decreases the binding of ZNF143 to the STAF binding site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Induced G2/M arrest.
In the PC‐3 xenograft model, YPC‐22026 (75 mg/kg; ip) significantly decreases in the intratumoral expression levels of all ZNF143 target genes, RAD51, PLK1, and Survivin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six‐week‐old male BALB/c nude mice injected with HCT116 cells[1]
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Dosage:50 mg/kg and 100 mg/kg
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Administration:i.p; on days 1, 2, 3, 8, 9, 12, and 16 (50 mg/kg ); on days 1, 2, 3, 12, and 16 (100 mg/kg)
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Result:Significantly inhibited the growth of tumors.
Chemical Information
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No. CAS 1964457-41-7
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Peso molecular 331.25
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Fòrmula C16H8F3N3O2
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SMILES
FC(F)(F)OC1=CC=CC=C1C2=NN=C(C#CC3=CC=CN=C3)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YPC-22026 Related Classifications
HY-120264 Related Classifications
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