YTP-17
Based on 1 Customer Validation
YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. YTP-17 shows anti-tumor efficacy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.04%
- No. CAS: 2714433-21-1
- Fòrmula: C26H25ClF2N2O4
- Peso molecular:502.94
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Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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YAP/TAZ-TEAD |
YTP-17 shows antiproliferative activity against NCI-H2052 cells with an IC50 of 45 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SCID mice bearing NCI-H226 cells[1]
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Dosage:60 mg/kg, 10 mL/kg
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Administration:Oral gavage; once daily; for 2 weeks
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Result:A 45% reduction in tumor volume.
Chemical Information
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No. CAS 2714433-21-1
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Appearance Solid
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Peso molecular 502.94
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Fòrmula C26H25ClF2N2O4
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Color White to off-white
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SMILES
FC1=CC2=C([C@@]([C@@]3=C(C=CC(OCCO)=C3F)C(NC)=O)=C1Cl)C[C@](C4=CC=CC=C4)(CNC)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (198.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9883 mL | 9.9415 mL | 19.8831 mL | 49.7077 mL |
| 5 mM | 0.3977 mL | 1.9883 mL | 3.9766 mL | 9.9415 mL | |
| 10 mM | 0.1988 mL | 0.9942 mL | 1.9883 mL | 4.9708 mL | |
| 15 mM | 0.1326 mL | 0.6628 mL | 1.3255 mL | 3.3138 mL | |
| 20 mM | 0.0994 mL | 0.4971 mL | 0.9942 mL | 2.4854 mL | |
| 25 mM | 0.0795 mL | 0.3977 mL | 0.7953 mL | 1.9883 mL | |
| 30 mM | 0.0663 mL | 0.3314 mL | 0.6628 mL | 1.6569 mL | |
| 40 mM | 0.0497 mL | 0.2485 mL | 0.4971 mL | 1.2427 mL | |
| 50 mM | 0.0398 mL | 0.1988 mL | 0.3977 mL | 0.9942 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8285 mL | |
| 80 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.6213 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4971 mL |
YTP-17 Related Classifications
HY-150256 Related Classifications
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