Zosurabalpin
Based on 1 Customer Validation
Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB2FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) .
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- Pureza: 99.28%
- No. CAS: 2379336-76-0
- Fòrmula: C43H50N8O5S
- Peso molecular:790.97
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Zosurabalpin inhibits all Acinetobacter spp [4].
Zosurabalpin (0.01-10 μM; 24 h) inhibits LPS transport by wild-type LptB2FGC to LptA [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A. baumannii isolates
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Concentration:0.01, 0,1, 1, and 10 μM
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Incubation Time:24 h
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Result:Reduced the extraction of LPS in a concentration-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cyclophosphamide monohydrate (HY-17420A) and bacterial suspension treaded male CD-1 mice [3]
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Dosage:6-360 mg/kg/day
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Administration:Subcutaneous injection (s.c.), every 6 h for 24 h
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Result:Decreased in bacterial burden in a dose-dependent manner.
Chemical Information
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No. CAS 2379336-76-0
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Appearance Solid
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Peso molecular 790.97
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Fòrmula C43H50N8O5S
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Color White to off-white
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SMILES
O=C1NCC2=C(C3=CC=C(C=C3)C(O)=O)C=CC=C2SC4=NC=CC=C4CN[C@H](C(N[C@H](C(N([C@H]1CC5=CNC6=CC=CC=C56)C)=O)CCCCN)=O)CCCN
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Synonyms
Abx MCP; RG6006
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 4.17 mg/mL (5.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Weng Q, et al. Zosurabalpin: a novel tethered macrocyclic peptide antibiotic that kills carbapenem-resistant Acinetobacter baumannii. MedComm (2020). 2024 Aug 11;5(8):e696. [Content Brief]
[2]. Skudlarek JW, et al. Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy. J Med Chem. 2024 Sep 12;67(17):15620-15675. [Content Brief]
[3]. Zampaloni C, et al. A novel antibiotic class targeting the lipopolysaccharide transporter. Nature. 2024 Jan;625(7995):566-571. doi: 10.1038/s41586-023-06873-0. Epub 2024 Jan 3. Erratum in: Nature. 2024 Jul;631(8022):E17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2643 mL | 6.3214 mL | 12.6427 mL | 31.6068 mL |
| 5 mM | 0.2529 mL | 1.2643 mL | 2.5285 mL | 6.3214 mL |
Zosurabalpin Related Classifications
HY-147429 Related Classifications
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