FOXO6 - forkhead box O6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 100132074

About FOXO6

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,361,434-41,383,590 (from NCBI)

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of dendritic spine development and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FOXO6 Products (1)

mRNA Protein Name
NM_001291281.3 NP_001278210.2 forkhead box protein O6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23714368 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXO6 Protein Structure

Forkhead

Forkhead: Forkhead domain (91 - 173)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

forkhead box protein O6

FOXO6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXO6 A8MYZ6 HNF4A Homo sapiens P41235
Anti Bait CoIP
23714368
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rhabdomyosarcoma 2

  • Alveolar Rhabdomyosarcoma

  • Rhabdomyosarcoma, Alveolar

  • Rhabdomyosarcoma Alveolar

  • RMS2

  • Rmsa

  • Rhabdomyosarcoma 2, Alveolar

  • Alveolar Childhood Rhabdomyosarcoma

  • Arms

  • Rhabdomyosarcoma, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05072 FOXO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22515 Foxo6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29036 Foxo6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FOXO6 VGNC VGNC:59182
Felis catus FOXO6 VGNC VGNC:107546
Macaca mulatta FOXO6 VGNC VGNC:99955
Rattus norvegicus FOXO6 RGD RGD:1595858
Mus musculus FOXO6 MGD MGI:2676586
Others FOXO6 NCBI