PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

Homo sapiens

Also known as IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3

Gene ID: 10039 | Gene type: protein coding

About PARP3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,942,363-51,948,867 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of Apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PARP3 Products(6)

mRNA	Protein	Name
NM_001370239.1	NP_001357168.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001370240.1	NP_001357169.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_005485.6	NP_005476.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003931.4	NP_001003931.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003935.2
XM_047447087.1	XP_047303043.1	protein mono-ADP-ribosyltransferase PARP3 isoform X1

PARP3 Protein Structure

WGR

PARP_reg

PARP

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

protein mono-ADP-ribosyltransferase PARP3

ADP-ribosyltransferase (NAD+	poly (ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+	poly (ADP-ribose) polymerase)-like 3
ADP-ribosyltransferase diphtheria toxin-like 3	ADPRT-3
DNA ADP-ribosyltransferase PARP3	NAD(+) ADP-ribosyltransferase 3
NAD+ ADP-ribosyltransferase 3	poly [ADP-ribose] polymerase 3
poly(ADP-ribose) synthetase-3	poly[ADP-ribose] synthase 3
poly[ADP-ribose] synthetase 3

Recombinant PARP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75955	PARP3 Protein, Human (sf9, His-GST)	Q9Y6F1 (M1-L533)	≥95%

Related Diseases

Diseases

Alias

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.80%	Yes
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.76%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13536	AZD-2461	Inhibitor	99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-148566	OUL232	Inhibitor	99.82%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.89%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-155993	YCH1899	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PARP3	VGNC	VGNC:80647
Macaca mulatta	PARP3	VGNC	VGNC:84055
Mus musculus	PARP3	MGD	MGI:1891258
Rattus norvegicus	PARP3	RGD	RGD:1305189
Canis familiaris	PARP3	VGNC	VGNC:81897
Others	PARP3	NCBI

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