PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

Also Known as IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10039

About PARP3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,942,363-51,948,867 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the PARP family. These Enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of Apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PARP3 Products (6)

mRNA	Protein	Name
NM_001370239.1	NP_001357168.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001370240.1	NP_001357169.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_005485.6	NP_005476.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003931.4	NP_001003931.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003935.2
XM_047447087.1	XP_047303043.1	protein mono-ADP-ribosyltransferase PARP3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD DNA ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	29361132	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	20064938	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	21211721	GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	20064938	GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	20064938	GOA
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20064938	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA ADP-ribosylation	IDA IDA: Inferred from direct assay	29361132	GOA
acts upstream of or within double-strand break repair	IDA IDA: Inferred from direct assay	21270334	GOA
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	21211721	GOA
acts upstream of or within positive regulation of DNA ligation	IGI IGI: Inferred from genetic interaction	21211721	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	24598253	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA
acts upstream of or within protein localization to site of double-strand break	IMP IMP: Inferred from mutant phenotype	21211721	GOA
NOT involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA
acts upstream of or within regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	21270334	GOA
acts upstream of or within telomere maintenance	IMP IMP: Inferred from mutant phenotype	21270334	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in site of double-strand break	IDA IDA: Inferred from direct assay	21270334	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP3 Protein Structure

WGR

PARP_reg

PARP

0
100
200
300
400
500
533 a.a.

Protein Preferred Names	Protein Names
protein mono-ADP-ribosyltransferase PARP3	ADP-ribosyltransferase (NAD+ poly (ADP-ribose) polymerase)-like 2 ADP-ribosyltransferase (NAD+ poly (ADP-ribose) polymerase)-like 3 ADP-ribosyltransferase diphtheria toxin-like 3 ADPRT-3 DNA ADP-ribosyltransferase PARP3 NAD(+) ADP-ribosyltransferase 3 NAD+ ADP-ribosyltransferase 3 poly [ADP-ribose] polymerase 3 poly(ADP-ribose) synthetase-3 poly[ADP-ribose] synthase 3 poly[ADP-ribose] synthetase 3

Related Diseases

Diseases	Alias
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.96%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.91%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150207	RBN-3143	Inhibitor	99.29%	Phase 1
HY-13536	AZD-2461	Inhibitor	99.79%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.72%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-178032	PARP1-IN-44	Inhibitor	/	Unkown
HY-172806	PARP14 inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PARP3	VGNC	VGNC:80647
Macaca mulatta	PARP3	VGNC	VGNC:84055
Mus musculus	PARP3	MGD	MGI:1891258
Rattus norvegicus	PARP3	RGD	RGD:1305189
Canis familiaris	PARP3	VGNC	VGNC:81897
Others	PARP3	NCBI